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Стартап
DateDate: 30-04-2019, 06:34

The CRISPR genome editing technology was developed initially with the aim of providing treatment and prevention of genetic diseases, but later this technology, which turned into a powerful tool, found application in several other areas, including synthetic biology. Recently, researchers from the Swiss Federal Institute of Technology in Zurich (Swiss Federal Institute of Technology, ETH Zurich) used CRISPR technology to create functional biocomputers embedded directly into human tissue cells.
Note that living organisms can already be considered a kind of biocomputers, the cells of which play the role of logical elements, drawing input data from the outside, processing this data and reacting to them by certain metabolic processes. "The human body itself is a big bio-computer," says Martin Fusseenegger (Martin Fussenegger), lead researcher, food".
The use of natural processes occurring inside living cells to build logical circuits is one of the main goals of synthetic biology. In this case, researchers from ETH Zurich found a way to introduce a dual-core bioprocessor into human cells, and a specially developed version of the Cas9 enzyme used in CRISPR technology was used as such a bioprocessor.
The Cas9 enzyme reads the initial data from the RNA molecule and on the basis of these data activates or deactivates certain genes, which, in turn, leads to the production of specific proteins by the cell. A feature of the Cas9 enzyme is that it has two “digital inputs”; it can simultaneously read two numbers, process them, and produce two independent results. In other words, this enzyme, introduced into the cell nucleus, is a simple dual core bioprocessor capable of performing two independent tasks.
Billions of such cells equipped with bioprocessors can be combined in the future into powerful bio-computers capable of diagnosing and independently curing various diseases. These computers will search for specific biomarkers corresponding to various diseases, and produce drug molecules. Depending on the number of detected biomarkers, the biocomputer will produce medicinal molecules of different types that will act as efficiently as possible in each particular case.
DNA-based artificial material behaves almost like a living organism.
“Imagine an implant consisting of human-patient tissues whose millions or billions of cells contain binuclear bioprocessors,” says Martin Fassenegger, “Such“ computational ”bodies can theoretically have a computing power far surpassing that of digital supercomputers. a biological supercomputer will require a very small amount of energy, which cannot be compared even with the amount of energy consumed by an ordinary desktop computer. m "





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